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| Stemolecule™ Wnt Inhibitor IWP-4 |
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| Description |
| Stemolecule™ Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway1. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It has an IC50 of 25 nM and blocks phosporylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Figure 1 |
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| Details |
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| Products |
| Stemolecule Wnt Inhibitor IWP-4 |
- 2 mg
- Stemgent Catalog # 04-0036
130-095-586
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| References |
| 1. Chen et al. (2009) Nat Chem Biol 5: 100–107. |
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