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| Stemolecule™ SHH Antagonist |
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| Description |
| Stemolecule™ SHH Antagonist is an inhibitor of Sonic hedgehog signaling (SHH)1. Hedgehog signaling plays key roles in a wide variety of development process2 as well as cancer progression3. The vertebrate family of hedgehog genes that have been identified are known as Sonic (Shh), Desert (Dhh), and Indian (Ihh) hedgehogs, all of which encode secreted proteins. Among the three, Sonic hedgehog (SHH) is the best studied ligand of the vertebrate pathway. One of the best studied examples is the action of Sonic hedgehog during development of the vertebrate limb, in which both the concentration and the time of exposure to SHH determines which digit into which the tissue will develop4. Stemolecule™ SHH Antagonist is the result of a compound screening for inhibiting activation of the hedgehog signaling pathway, e.g. inhibition of aberrant growth states resulting from phenotypes such as hedgehog gain-of-function1. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule SHH Antagonist |
- 2 mg
- Stemgent Catalog # 04-0032
130-095-582
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| References |
| 1. World Patent WO 2006050351 (2006). |
| 2. Ingham and McMahon (2001) Genes Dev 15: 3059–3087. |
| 3. Jiang and Hui (2008) Dev Cell 15: 801–812. |
| 4. Harfe et al. (2004) Cell 118: 517–528. |
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