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| Description |
| Stemolecule™ IDE-2 was identified in a high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells1. IDE-2 is able to generate Sox17+/FoxA2+ cells to an equal or greater efficiency than that of protein (i.e. Activin A or Nodal) inducers of definitive endoderm in mouse or human ES cell cultures1. It has an EC50 of 223 nM and functions in part via activation of TGF-β signaling, as evident by Smad2 phosphorylation1. Endoderm chemically induced by IDE-2 can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos1. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
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| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule IDE-2 |
- 2 mg
- Stemgent Catalog # 04-0027
130-095-577
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| References |
| 1. Borowiak et al. (2009) Cell Stem Cell 4: 348–358. |
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