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| Stemolecule™ Dorsomorphin |
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| Description |
| Stemolecule™ Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki=109nM)1 and bone morphogenic protein (BMP) signaling2. Dorsomorphin was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish3. Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation3. BMP signaling coordinates developmental patterning and have essential physiological roles in mature organisms4,5. Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis3, cardiomyogenesis6 and osteogenesis7. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule Dorsomorphin |
- 2 mg
- Stemgent Catalog # 04-0024
130-095-574
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| References |
| 1. Gao et al. (2008) Biol Pharm Bull 31: 1716–1722. |
| 2. Anderson and Darshan (2008) Nat Chem Biol 4: 15–16. |
| 3. Yu et al. (2008) Nat Chem Biol 4: 33–41. |
| 4. Heisenberg, C.P. and Solnica-Krezel, L. (2008) Curr. Opin. Genet. Dev. 18: 311–316. |
| 5. Cain et al. (2008) Differentiation 76: 831–842. |
| 6. Hao et al. (2008) PLoS ONE 3: e2904. |
| 7. Seib et al. (2009) Eur J Cell Biol 88: 257–271. |
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