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| Description |
| Stemolecule™ Cyclopamine is a steroid alkaloid isolated from the corn lily (Veratrum californicum) and originally identified as a teratogenic agent1. Cyclopamine has since been identified as a specific inhibitor of hedgehog singaling by direct binding to the heptahelical bundle of Smoothened2. Hedgehog signaling is involved in embryogenesis as well as cancer progression3. Cyclopamine has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells4, as a modulator of cell proliferation5, and as an anticancer drug6. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
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| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule Cyclopamine |
- 2 mg
- Stemgent Catalog # 04-0022
130-095-572
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| References |
| 1. Gaffield et al. (1999) Cell Mol Biol (Noisy-le-grand) 45: 579–588. |
| 2. Chen et al. (2002) Genes Dev 16: 2743–2748. |
| 3. Jiang and Hui (2008) Dev Cell 15: 801–812. |
| 4. D'Amour et al. (2006) Nat Biotechnol 24: 1392–1401. |
| 5. Gallo et al. (2008) Ann N Y Acad Sci 1150: 43–45. |
| 6. Xu et al. (2009) Cancer Lett: |
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