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| Stemolecule™ All-Trans Retinoic Acid |
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| Description |
| Stemolecule™ All-Trans Retinoic Acid is the oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation1 and proliferation2. It acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions activating gene transcription3. All-Trans Retinoic Acid has been implicated in specification of the embryonic anterior/posterior axis through Hox gene regulation4. It has been used in various differentiation protocols, including B-cells2, T cells5 and neurons6-9, and applied clinically to treat cancer as a form of differentiation-induction therapy10,11. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule All-Trans Retinoic Acid |
- 100 mg
- Stemgent Catalog # 04-0021
130-095-571
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| References |
| 1. Duester (2008) Cell 134: 921–931. |
| 2. Ertesvag et al. (2009) Semin Immunol 21: 36–41. |
| 3. Marshall et al. (1996) FASEB J 10: 969–978. |
| 4. Holland (2007) Nature 447: 153–155. |
| 5. Yagi et al. (1997) Cell Immunol 181: 153–162. |
| 6. Dhara and Stice (2008) J Cell Biochem 105: 633–640. |
| 7. Sasai (2002) J Neurol 249 Suppl 2: II41–II44. |
| 8. Takahashi et al. (1999) J Neurobiol 38: 65–81. |
| 9. Wichterle et al. (2002) Cell 110: 385–397. |
| 10. Collins (2008) Curr Opin Hematol 15: 346–351. |
| 11. Mongan and Gudas (2007) Differentiation 75: 853–870. |
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