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| Stemolecule™ ALK5 Inhibitor |
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| Description |
| Stemolecule™ ALK5 Inhibitor is a selective and ATP-competitive inhibitor of a TGF-β family type I receptor, activin receptor-like kinase (ALK5)1. Inhibition of TGF-β signaling increased the efficiency of reprogramming of rat liver progenitor cells and IMR90 human fibroblast cells to mouse embryonic stem (ES) cell-like induced pluripotent stem (iPS) cells, as well as maintained these cells in an undifferentiated state for over 30 passages2. The mouse ES cell culture condition together with inactivation of TGF-β signaling provided a robust culturing method of reprogrammed rat and human iPS cells2. This study indicates the significant role of TGF-β signaling in regulating ES cell fate determination, and provides a novel method for culture of rat and human iPS cells. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Figure 1 |
| Stemolecule™ ALK5 Inhibitor. |
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| Details |
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| Products |
| Stemolecule ALK5 Inhibitor |
- 1 mg
- Stemgent Catalog # 04-0015
130-095-566
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| References |
| 1. Gellibert et al. (2004) J Med Chem 47: 4494–4506. |
| 2. Li et al. (2008) Cell Stem Cell 4: 16–19. |
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