|
|
 |
| Stemolecule™ SC1 (Pluripotin) |
|
| Description |
| SC1 (Pluripotin) was identified in a cell-based screen of a chemical library for small molecules that regulate the mouse embryonic stem (ES) cell self-renewal1. It was shown that SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Inactivation of ERK1 blocks differentiation, whereas inhibition of Ras-GAP activates Ras and PI3K, promoting self-renewal of mouse ES cells. Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo. |
| Disclaimer |
| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
|
| |
|
| Figure 1 |
| The use of SC1 (Pluripotin) to support mESC self-renewal in the absence of LIF. |
 |
|
| Figure 2 |
 |
|
|
|
|
| Favorites / Prices |
Request prices or add products to your favorite list.
|
| Details |
|
| Products |
| Stemolecule SC1 (Pluripotin) |
- 1 mg
- Stemgent Catalog # 04-0011
130-095-562
|
|
| References |
| 1. Chen et al. (2006) Proc Natl Acad Sci USA 103 (46): 17266–17271. |
|
| MACS Stem Cell newsletter |
|
Stay current with important developments in stem cell research by subscribing to
Stem Cell Updates.
|
|
© 1999 - 2012 Miltenyi Biotec ¦ Terms & conditions ¦ Legal notes
|
