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| Description |
| SB431542 is an inhibitor of the transforming growth factor-beta 1 (TGF-β1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGF-β signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -61, 2. Watabe and colleagues (2003) reported that at a concentration of 1μM, SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells3. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Figure 1 |
| Stemolecule™ SB431542 chemical structure. |
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| Details |
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| Products |
| Stemolecule SB431542 |
- 5 mg
- Stemgent Catalog # 04-0010
130-095-561
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- 10 mg
- Stemgent Catalog # 04-0010-10
130-097-448
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| References |
| 1. Laping et al. (2002) Mol. Pharmacol. 62: 58–64. |
| 2. Inman et al. (2002) Mol. Pharmacol. 62: 65–74. |
| 3. Watabe et al. (2003) J. Cell Biol. 163 (6): 1303–1311. |
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