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| Description |
| Stemolecule™ PD173074 is a potent, cell-permeable and ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor1. Inhibition of the FGF signaling pathway leads to self-renewal of stem cells in many systems. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 significantly decreased their clonogenicity and differentiation potential2. Also, differentiation of mouse embryonic stem (ES) cells requires auto-inductive stimulation of the mitogen-activated protein kinase pathway by FGF43,4 including autocrine FGF45. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data Sheets
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| Figure 1 |
| Stemolecule™ PD0325901 chemical structure. |
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| Details |
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| Products |
| Stemolecule PD173074 |
- 2 mg
- Stemgent Catalog # 04-0008
130-095-559
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| References |
| 1. Mohammadi et al. (1998) EMBO J. 17: 5896–5904. |
| 2. Zaragosi et al. (2006) Stem Cells 24: 2412–2419. |
| 3. Kunath et al. (2007) Development 134: 2895–2902. |
| 4. Stavridis et al. (2007) Development 134: 2889–2894. |
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