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| Stemolecule™ Sodium Butyrate |
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| Description |
| Sodium butyrate is the sodium salt of the short-chain fatty acid butyric acid1. Butyrate is a metabolite of intestinal bacteria and a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract2. The effects of sodium butyrate on cell volume regulation and chloride transport in the rat distal colon were first described by M. Diener et al. in 19973. Sodium butyrate is a known inhibitor of histone deacetylases4,5. The enhancement and suppression of various cytokines in stimulated human monocytes using sodium butyrate was first reported in 20002. In cultured mouse and human cells, sodium butyrate has been shown to inhibit both the mRNA and protein level of cyclin D16. |
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| This Stemgent® Product is exclusively distributed by Miltenyi Biotec outside the USA and Israel. |
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| Specification SheetsMaterial Safety Data Sheets
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| Details |
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| Products |
| Stemolecule Sodium Butyrate |
- 500 mg
- Stemgent Catalog # 04-0005
130-095-556
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| References |
| 1. Kolthoff et al. Quantitative Chemical Analysis, 4th ed., MacMillan Pub. (New York, NY: 1969). |
| 2. Saemann et al. (2000) FASEB J. 14 (15): 2380–2382. |
| 3. Diener and Scharrer (1997) Biochem. Physiol. A Physiol. 118 (2): 375–379. |
| 4. Kruh (1982) Mol. Cell. Biochem. 42 (2): 65–82. |
| 5. Ware et al. (2009) Cell Stem Cell 4 (4): 359–369. |
| 6. Lallemand et al. (1996) Biochem. Biophys. Res. Commun. 229 (1): 163–169. |
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