| Description |
| CD117 MicroBeads were developed for the isolation of mouse progenitor cells. CD117, also known as c-kit, steel factor receptor, or stem cell factor receptor (SCF-R), encodes a 145 kDa cell surface glycoprotein belonging to the class III receptor tyrosine kinase family. It is expressed on the majority of hematopoietic progenitor cells, including multipotent hematopoietic stem cells, as well as on nonhematopoietic stem cells. Furthermore, it is found on committed myeloid, erythroid, and lymphoid precursor cells and on a few mature hematopoietic cells, e.g. mast cells. |
| Applications |
| CD117+ stem cells from bone marrow were reported to be capable of differentiating into smooth muscle cells, myocytes, and endothelial cells in vivo.1,2 Also, CD117+ cells from amniotic fluid show broad multipotent differentiation potential.3 |
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| Figure 1 |
Separation of bone marrow cells using CD117 MicroBeads, a MiniMACS™ Separator, and an MS Column.
Lineage marker: (CD5, CD11b, CD45R, Gr-1, 7-4, Ter-119)-Biotin/Anti-Biotin-APC. |
| A: Before enrichment |
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| B: CD117+ cells |
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