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| Overview |
| VEGF stands for vascular endothelial growth factor, also termed VEGF-A. Several alternatively spliced isoforms have been identified in mice. Mouse VEGF (164 aa) is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information
VEGF is a disulfide-linked, homodimer which is active in angiogenesis, vasculogenesis, and endothelial cell growth. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. VEGF signals through receptor tyrosine kinases VEGFR1 (also called Flt1) and VEGFR2 (Flk1 / KDR) on endothelial cells. Several isoforms arise by alternative splicing of the mRNA; the soluble 164 amino acid form of the factor has been identified in mouse, the 165 amino acid isoform was found in humans. The biological activities of VEGF are not species-specific.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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