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| Stemgent® Affinity Purified anti-Mouse/Human Nanog Antibody |
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| Description |
| Affinity Purified anti-Mouse/Human Nanog was screened on human and mouse ES cells using ICC and selected as the best Nanog antibody available for researchers needing to demonstrate pluripotency. Nanog is a member of the homeobox family of DNA binding transcription factors and has been shown to maintain embryonic stem (ES) cell self-renewal independently of leukemia inhibitory factor (LIF)/Stat31,2. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Functionally, Nanog works together with other key pluripotent factors (Oct4, Sox2, and Lin28) to reprogram human fibroblasts and generate induced pluripotent stem (iPS) cells3. These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells4,5. |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data SheetsProtocols
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| Figure 1 |
| Immunocytochemistry Analysis of Mouse ES Cell Line R1. |
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| Figure 2 |
| Immunocytochemistry Analysis of Human ES Cell Line H1. |
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| Details |
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| Products |
| Stemgent® Affinity Purified anti-Mouse/Human Nanog Antibody |
- 100 µL
- Stemgent Catalog #09-0020
130-095-632
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| References |
| 1. Mitsui et al. (2003) Cell 113: 631-642 |
| 2. Chambers et al. (2003) Cell 113: 643-655 |
| 3. Yu et al. (2007) Science 318: 1917-1920 |
| 4. Pan and Thomson (2007) Cell Res 17: 42-49 |
| 5. Kim et al. (2008) Cell 132: 1049-1061 |
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