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| Stemgent® Purified Rabbit anti-Mouse/Human Oct4 Antibody |
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| Description |
| Octamer-4 (Oct4), a homeodomain transcription factor of the POU family (POU5F1) is involved in regulation of pluripotency during normal development. The expression of Oct4 is associated with an undifferentiated phenotype in embryonic stem (ES) cells, while gene knockdown of Oct4 promotes differentiation. As such, it is frequently used as a marker for undifferentiated ES cells or iPS (induced pluripotent stem) cells. Oct4 is one of the four key transcription factors (Oct4, Sox2, c-Myc, and Klf4) used to reprogram mouse and human fibroblasts to a pluripotent state.1-5 |
| Specifications and technical documents |
| Specification SheetsMaterial Safety Data SheetsProtocols
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| Figure 1 |
| Immunocytochemistry Analysis of Mouse ES Cell Line R1. |
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| Figure 2 |
| Immunocytochemistry Analysis of Human ES Cell Line H1. |
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| Figure 3 |
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| Details |
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| Products |
| Stemgent Purified Rabbit anti-Mouse/Human Oct4 Antibody |
- 100 µL
- Stemgent Catalog #09-0023
130-095-635
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| References |
| 1. Leendert et al. (2003) Cancer Res 63: 2244–2250 |
| 2. Zaehres et al. (2005) Stem Cells 23: 299–305 |
| 3. Takahashi and Yamanaka (2006) Cell 126: 663–676. |
| 4. Takahashi et al. (2007) Cell 131: 861–872 |
| 5. Park et al. (2008) Cell 134: 877–886 |
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