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| Overview |
| Anti-A2B5 MicroBeads have been developed for positive selection of human, murine and rat A2B5+ glial progenitor cells. |
| Details |
Background information
A2B5 is predominantly expressed in embryonic and neonatal neural tissue. In adult mammalian brain A2B5 expression is restricted mainly to areas that retain neurogenic potential such as the subventricular zone (SVZ). Thus, A2B5 is considered to be a marker for immature glial-committed precursors that are permanently generated in the SVZ.
Ganglioside GT3 and its O-acetylated derivative are the principal A2B5-reactive gangliosides, and both antigens are down-regulated as the cells differentiate into mature oligodendrocytes.
Glial progenitors from embryonic to adult human, murine, and rat tissue have been immunomagnetically isolated according to the expression of A2B51–5. |
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| Details |
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| Products |
| Anti-A2B5 MicroBeads, human, mouse, rat |
- for 109 total cells
Download datasheet
130-093-388
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| References |
| 1. Windrem et al. (2004) Nat. Med. 10: 93–97. |
| 2. Ruffini et al. (2004) Am. J. Pathol. 165: 2167–2175. |
| 3. Larsen, P.H. and Yong, V.W. (2004) J. Neurosci. 24: 7597–7603. |
| 4. Larsen et al. (2006) J. Neurosci. 26: 2207–2214. |
| 5. Larsen et al. (2003) J. Neurosci. 23: 11127–11135. |
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