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| CD62L (L-selectin) MicroBeads |
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| Description |
| Mouse CD62L (L-selectin) MicroBeads were developed for the positive selection or depletion of T cell subsets from lymph nodes or spleen. |
| Details |
Background information
CD62L is highly expressed on naive T cells and down-regulated upon activation. It is also expressed on a small subset of memory T cells, the central memory T cells, which can be distinguished from naive T cells by their high expression of CD44. Furthermore, CD62L is expressed on most thymocytes, naive cytotoxic T cells, B cells, dendritic cells, macrophages, NK cells, neutrophils, and eosinophils.
For isolation of CD4+CD62L+ naive T cells, the CD4+CD62L+ T Cell Isolation Kit II is available.
Downstream applications
Naive T cells isolated following a MultiSort strategy were used for studies on cytokine expression,1,2 receptor signaling,3 and T cell activation by different antigen-presenting cells.4 |
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| Figure 1 |
| Two step isolation of naive and effector/memory T cells using a T cell-specific FITC-conjugated antibody, Anti-FITC-MultiSort Kit, and CD62L MicroBeads. |
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| Details |
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| Products |
| CD62L (L-selectin) MicroBeads, mouse |
- for 2×109 total cells
Download datasheet
130-049-701
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| References |
| 1. Assenmacher et al. (1998) J. Immunol. 161: 2825–2832. |
| 2. Assenmacher et al. (1998) Eur. J. Immunol. 28: 1534–1543. |
| 3. Flynn et al. (1998) J. Exp. Med. 188: 297–304. |
| 4. Aloisi et al. (1999) Eur. J. Immunol. 29: 2705–2714. |
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