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| GadoSpin™ D, MRI contrast agent |
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| Description |
GadoSpin D is a dendritic gadolinium-based contrast agent of intermediate molecular weight specifically formulated for preclinical magnetic resonance imaging (MRI).
It is a contrast agent of high relaxivity increasing the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin D remains within the vascular system. Significant extravasation can be observed in fenestrated blood vessels of inflamed tissue or tumors.
GadoSpin D is mainly excreted via glomerular filtration (kidneys). |
| Applications |
GadoSpin D is indicated for use in MRI of small animals, for example, mice, to facilitate the visualization of the vasculature.
Examples include dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), tumor characterization and therapy monitoring. |
| Disclaimer |
For laboratory and animal research use only.
Warning: Not for human or animal therapeutic or diagnostic use.
Make sure to comply with all laws and regulations governing research on animals. |
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| Figure 1 |
| Schematic diagram of GadoSpin™ D. |
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| Details |
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| Products |
| GadoSpin D |
- 5 injections (1)
Components
- 1 vial
Download datasheet
130-095-164
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- 25 injections (1)
Components
- 5 vials
Download datasheet
130-095-165
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| (1) One vial contains 850 μL of imaging agent, sufficient for 5 injections of the recommended volume of 100 μL (for a 20–30 g mouse). |
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| References |
| 1. Su, M. Y. et al. (2002) Technol. Cancer Res. Treat. 1: 479–488. |
| 2. Verhoye, M. et al. (2002) Magn. Reson. Med 47: 305–313. |
| 3. Fink, C. et al. (2003) J. Magn. Reson. Imaging 18: 59–65. |
| 4. Hamzah, J. et al. (2008) Nature 453: 410–414. |
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