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| NiraWave™ C, optical contrast agent |
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| Description |
NiraWave C is a near-infrared (NIR) fluorescence contrast agent with high protein binding affinity specifically formulated for preclinical optical imaging.
It shows absorption and emission (fluorescence) in the NIR spectral range allowing an increased tissue penetration.
Upon intravenous injection, NiraWave C rapidly binds to plasma proteins and is excreted unchanged by the liver. The plasma clearance is biphasic with an initial half-life of 3–4 minutes and a secondary half-life of more than 1 hour. |
| Applications |
NiraWave C is indicated for use in optical imaging of small animals, for example mice, to facilitate the visualization of the vasculature.
Examples include fluorescence angiography. |
| Disclaimer |
For laboratory and animal research use only.
Warning: Not for human or animal therapeutic or diagnostic use.
Make sure to comply with all laws and regulations governing research on animals. |
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| Figure 1 |
| Structural formula of indocyanine green. |
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| Figure 2 |
| Normalized absorption and emission spectra of NiraWave C in plasma. |
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| Details |
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| Products |
| NiraWave C |
- 5 injections (1)
Components
- 1 vial
Download datasheet
130-095-154
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- 25 injections (1)
Components
- 5 vials
Download datasheet
130-095-155
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| (1) After reconstitution one vial contains 850 μL of imaging agent, sufficient for 5 injections of the recommended volume of 100 μL (for a 20–30 g mouse). |
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| References |
| 1. Reynolds, J. S. et al. (1999) Photochem. Photobiol. 70: 87–94. |
| 2. Li et al. (1995) Proc. SPIE. 2389: 789–797. |
| 3. Bäumler, W. et al. (1999) Br. J. Cancer. 80: 360–363. |
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