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| NiraWave™ M, optical contrast agent |
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| Description |
NiraWave M is a micellar near-infrared (NIR) fluorescence contrast agent exhibiting a prolonged blood circulation and high quantum yield specifically formulated for pre-clinical optical imaging.
NiraWave M shows absorption and emission (fluorescence) in the NIR spectral range allowing an increased tissue penetration.
Due to the micellar formulation of indocyanine green, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation. NiraWave M is excreted by the liver within hours. |
| Applications |
| NiraWave M is indicated for use in optical imaging of small animals, for example mice, to facilitate the visualization of the vasculature. Examples include fluorescence angiography and fenestration of blood vessels in inflamed tissue or tumors. |
| Disclaimer |
For laboratory and animal research use only. Warning: Not for human or animal therapeutic or diagnostic use. Make sure to comply with all laws and regulations governing research on animals. |
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| Figure 1 |
| Structural formula of indocyanine green and schematic diagram of its incorporation into micelles as in Nirawave™ M. |
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| Figure 2 |
| Normalized absorption and emission spectra of NiraWave™ M in plasma. |
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| Details |
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| Products |
| NiraWave M |
- 5 injections (1) Components - 1 vial dye - 1 vial reconstitution medium Download datasheet 130-095-156
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- 25 injections (1) Components - 5 vials dye - 5 vials reconstitution medium Download datasheet 130-095-157
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| (1) After reconstitution one vial contains 850 μL of imaging agent, sufficient for 5 injections of the recommended volume of 100 μL (for a 20–30 g mouse). |
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| References |
| 1. Kirchherr, A. K. et al. (2009) Mol. Pharmaceutics. 6: 480–491. |
| 2. Kirchherr, A. K. (2010) PhD thesis. |
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