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| MACS® GMP Recombinant Human IL-21 |
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| Overview |
Interleukin 21 (IL-21) has pleiotropic effects on both cellular and humoral immune responses, such as stimulation of lymphocyte proliferation, promotion of CD8+ T cell and NK cell cytotoxicity, and differentiation of B cells into plasma cells.
MACS GMP Recombinant Human IL-21 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for manufacture of this product. The product is lyophilized without carrier protein or preservatives. |
| Details |
Background information
IL-21 is a four α-helix bundle cytokine and closely related to IL-2, IL-7, and IL-15. IL-21 expression is restricted to activated CD4+ T helper cells and NKT cells. The functional receptor for IL-21, composed of the IL-21 receptor- and the common γ-chain, is expressed on various hematopoietic cells including T, B, NK and dendritic cells.
Applications
MACS GMP Recombinant Human IL-21 can be used for a variety of applications, including the ex vivo generation of antigen-specific cytotoxic T cells1,2 or the ex vivo stimulation of NK cells3.
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
A lot-specific certificate of analysis is provided, confirming identity, molecular mass, specific activity, sterility, purity, endotoxin content, host-cell DNA content, and host-cell protein content. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP Recombinant Human IL-21 |
| Availability: Worldwide (1) |
| Source: E. coli |
- 25 μg
Download datasheet
170-076-115
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Li and Yee (2008) Blood 111: 229-235. |
| 2. Hinrichs et al. (2008) Blood 111: 5326-5333. |
| 3. de Rham et al. (2007) Arthritis Res. Ther. 9: R125 |
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