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| MACS® GMP Recombinant Human IL-2 |
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| Overview |
Interleukin 2 (IL-2), a potent lymphoid cell growth factor, plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes, for instance, proliferation and differentiation of T cells, NK cells, and B cells.
MACS GMP Recombinant Human IL-2 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for manufacture of this product. The product is lyophilized without carrier protein or preservatives. |
| Details |
Background information
IL-2 is a typical four α-helix bundle cytokine and is produced by activated T cells, especially the CD4+ T helper cell population. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β-chain, and common γ-chain.
Applications
MACS GMP Recombinant Human IL-2 can be used for a variety of applications, including the ex vivo activation and expansion of T cells, e.g., antigen-specific cytotoxic T lymphocytes1,2 or regulatory T cells3 or the ex vivo stimulation of NK cells4,5.
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
A lot-specific certificate of analysis is provided, confirming identity, molecular mass, specific activity, sterility, purity, and endotoxin content. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP Recombinant Human IL-2 |
| Availability: Worldwide (1) |
| Source: E. coli |
- 20 μg
Download datasheet
170-076-113
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Zhang et al. (2007) J. Immunol. 179: 4910-4918. |
| 2. Hinrichs et al. (2008) Blood 111: 5326-5333 |
| 3. Peters et al. (2008) PLoS ONE 3(5): e2233. |
| 4. Berg et al. (2009) Cytotherapy 11: 341-355. |
| 5. McKenna et al. (2007) Transfusion 47: 520-528. |
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