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| MACS® GMP Recombinant Human IL-3 |
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| Overview |
Interleukin 3 (IL-3) is a hematopoietic growth factor with a broad spectrum of biologic activities. These include the stimulation of the proliferation and differentiation of immature pluripotent hematopoietic stem cells and various lineage-committed progenitor cells, leading to the production of most of the major blood cell types.
MACS GMP Recombinant Human IL-3 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for manufacture of this product. The product is lyophilized without carrier protein or preservatives. |
| Details |
Background information
IL-3 is mainly produced by activated T cells, but is also secreted by other cell types, including mast cells, eosinophils, and keratinocytes. Beside its role as hematopoietic growth factor, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils, and macrophages.
Applications
MACS GMP Recombinant Human IL-3 can be used for a variety of applications, including the ex vivo cultivation of human plasmacytoid dendritic cells from enriched CD304 (BDCA-4)+ cells.1-3
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
A lot-specific certificate of analysis is provided, confirming identity, molecular mass, specific activity, sterility, purity, endotoxin content, host-cell DNA content, and host-cell protein content. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP Recombinant Human IL-3 |
| Availability: Worldwide (1) |
| Source: E. coli |
- 25 μg
Download datasheet
170-076-110
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Grouard et al. (1997) J. Exp. Med. 185:1101-1111. |
| 2. Colonna et al. (2004) Nat. Immunol. 5:1219-1226. |
| 3. Cella et al. (2000) Nat. Immunol. 1:305-310. |
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