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| MACS® GMP Recombinant Human GM-CSF |
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| Overview |
Granulocyte-macrophage colony–stimulating factor (GM-CSF) is a hematopoietic growth factor, which is essential for proliferation and development of granulocyte and monocyte/macrophage progenitors.
MACS GMP Recombinant Human GM-CSF is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for manufacture of this product. The product is lyophilized without carrier protein or preservatives. |
| Details |
Background information
Beside its role as growth factor for granulocyte and monocyte precursors, GM-CSF also functions as a growth factor for erythroid and megakaryocytic precursor cells in conjunction with erythropoietin. GM-CSF is secreted by various cell types including T cells, macrophages, endothelial cells, and fibroblasts in response to inflammatory stimuli and cytokines. In addition, GM-CSF is a potent chemoattractant for neutrophils and eosinophils and enhances the effector functions of neutrophils and macrophages.
Applications
MACS GMP Recombinant Human GM-CSF can be used for a variety of applications, including the ex vivo generation of human dendritic cells from enriched CD14+ monocytes.1-3
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
A lot-specific certificate of analysis is provided, confirming identity, molecular mass, specific activity, sterility, purity, endotoxin content, host-cell DNA content, and host-cell protein content. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP Recombinant Human GM-CSF |
| Availability: Worldwide (1) |
| Source: E. coli |
- 25 μg
Download datasheet
170-076-112
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Bender et al. (1996) J. Immunol. Methods 196: 121–135. |
| 2. Romani et al. (1996) J. Immunol. Methods 196: 137–151. |
| 3. Jonuleit et al. (1997) Eur. J. Immunol. 27: 3135–3142. |
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