MACS® GMP Recombinant Human TNF-α
Description Tumor necrosis factor alpha (TNF-α) has its primary role in the regulation of immune cells. It is mainly produced by macrophages, but also by a broad variety of other cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. This cytokine is involved in systemic inflammation. TNF-α is involved in regulating apoptotic cell death, cellular proliferation, differentiation, and inflammation. MACS GMP Recombinant Human TNF-α is lyophilized without carrier protein or preservatives. A lot-specific certificate confirms identity, molecular mass, specific activity, sterility, purity, endotoxin content, and host-cell DNA content. Applications MACS GMP Recombinant Human TNF-α can be used for a variety of applications, including the ex vivo generation of human dendritic cells from enriched CD14+ monocyte populations.1-3 MACS GMP Recombinant Human TNF-α is not intended for human in vivo application. Quality Statement MACS GMP Recombinant Human TNF-α may be used for research or ex vivo cell culture processing. MACS GMP Recombinant Human TNF-α is manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. It is designed following the recommendations of USP <1043> on ancillary materials. No animal- or human-derived components are used for manufacturing.

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