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| MACS® GMP Recombinant Human IL-4 |
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| Overview |
Interleukin 4 (IL-4) is an anti-inflammatory cytokine and is a key regulator in humoral and adaptive immunity. It has complex biological roles and promotes growth and differentiation of B cells and T cells, and cells of the monocytic lineage.
MACS GMP Recombinant Human IL-4 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for manufacture of this product. The product is lyophilized without carrier protein or preservatives. |
| Details |
Background information
IL-4 is predominantly secreted by activated CD4+ memory and effector TH2 cells, basophils, and mast cells. It promotes the proliferation and differentiation of B cells, as well as immunoglobulin isotype switching, and MHC class II antigen and low-affinity IgE receptor expression. Furthermore, IL-4 induces the differentiation of naive CD4+ T cells into helper TH2 cells, while suppressing TH1 development, and promotes chemotaxis of mast cells and basophils.
Applications
MACS GMP Recombinant Human IL-4 can be used for a variety of applications, including the ex vivo generation of human dendritic cells from enriched CD14+ monocyte populations.1-3
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
A lot-specific certificate of analysis is provided, confirming identity, molecular mass, specific activity, sterility, purity, endotoxin content, host-cell DNA content, and host-cell protein content. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Favorites / Prices |
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| Details |
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| Products |
| MACS GMP Recombinant Human IL-4 |
| Availability: Worldwide (1) |
| Source: E. coli |
- 25 μg
Download datasheet
170-076-101
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- 250 μg
Download datasheet
170-076-135
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Bender et al. (1996) J. Immunol. Methods 196: 121–135. |
| 2. Romani et al. (1996) J. Immunol. Methods 196: 137–151. |
| 3. Jonuleit et al. (1997) Eur. J. Immunol. 27: 3135–3142. |
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