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| MACS® GMP PepTivator® EBV LMP2A |
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| Overview |
| The MACS GMP PepTivator EBV LMP2A is a peptide pool that consists mainly of 15-mer peptides with eleven amino-acid overlap. It has been developed for efficient in vitro stimulation and subsequent isolation EBV LMP2A-specific CD4+ and CD8+ T cells. |
| Details |
Background information
Epstein-Barr virus (EBV) is a human γ-herpesvirus with B cell growth–transforming ability and carcinogenic potential. More than 90% of human adults are infected with EBV. In healthy individuals, EBV typically establishes a persistent latent infection, in which the virus can be detected in resting, non-proliferating peripheral B lymphocytes. Expression of the viral protein latent membrane protein 2A (LMP2A) maintains the latency phase.
Applications
T cells are essential for the control of the outgrowth of EBV-infected B cells and LMP2A is one of the immunogenic targets. In EBV-associated malignancies, such as nasopharyngeal carcinoma and Hodgkin’s lymphoma, LMP2A is one in a restricted number of expressed viral proteins1.
Adoptive transfer of LMP2A-specific T cells may be an effective tool for the treatment of EBV-associated malignancies2.
The in vitro stimulation of LMP2A-specific CD4+ and CD8+ T cells with MACS GMP PepTivator EBV LMP2A causes the production of the effector cytokine IFN-gamma. The secretion of IFN-gamma then permits the enrichment of LMP2A-specific effector/memory T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
No animal-, human-, or virus-derived materials were used for manufacture of these products. |
| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP PepTivator EBV LMP2A |
| Availability: Worldwide (1) |
- 60 nmol/peptide for the stimulation of 109 cells
Download datasheet
170-076-122
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| (1) For availability in your country please contact your local representative. |
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| References |
| 1. Williams and Crawford (2006) Blood 107: 862–869. |
| 2. Bollard et al. (2007) Blood 110: 2838-45. |
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