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| MACS® GMP HCMV pp65 - Recombinant Protein |
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| Overview |
| GMP-grade recombinant protein to efficiently stimulate human cytomegalovirus-specific CD4+ and CD8+ T cells for your clinical research |
| Details |
Background information
Human cytomegalovirus (HCMV) is a member of the herpes virus group and belongs to the subfamily of beta-herpes viruses. Between 50 and 85% of human adults are infected with HCMV. Once infected, the virus persists in the organism. The infection is asymptomatic in healthy individuals but in immunocompromized patients HCMV can cause severe disease.
The pp65 protein (65 kDa lower matrix phosphoprotein), also known as glycoprotein 64 or UL83, is a virion tegument protein and the main component of the enveloped subviral particle. pp65 is an immunodominant target of CD4+ as well as CD8+ T cell responses to HCMV.
Applications
Antigen-specific T cells play a critical role in the regulation of immune responses and the elimination of virus-infected or malignant cells in the human body. Adoptive transfer of clinical-grade pp65-specific CD4+ and CD8+ T cells is a valuable tool for the treatment of HCMV infections after hematopoietic stem cell transplantation (SCT)1,2 and shows potential for solid organ transplantation (SOT)3.
The in vitro stimulation of pp65-specific CD4+ and CD8+ T cells with MACS® GMP HCMV pp65-Recombinant Protein causes the production of the effector cytokine IFN-gamma. The secretion of IFN-gamma then permits the enrichment of pp65-specific effector/memory T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).
Quality statement
MACS GMP Products are manufactured and tested under a certified ISO 9001 quality system and in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
No animal-, human-, or virus-derived materials were used for manufacture of these products.
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| Disclaimer |
| MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. |
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| Details |
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| Products |
| MACS GMP HCMV pp65 - Recombinant Protein |
| Availability: Worldwide |
- 1 mL (1)
Download datasheet
170-076-100
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| (1) 1 mL corresponds to the stimulation of 1x109 total cells |
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| References |
| 1. Einsele et al. (2002) Blood 99: 3916–3922. |
| 2. Mackinnon et al. (2008) Blood Cells Mol. Dis. 40: 63–67. |
| 3. Brestrich et al. (2009) Am J Transplant. Jul;9(7):1679-84. |
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