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| Overview |
| The functional grade antibody can be used for in vivo or in vitro functional assays, e.g. for blocking of the CD40/CD154 interaction. The antibody is free of azide and preservatives. Endotoxin level is <0.01 ng/µg protein as tested by LAL assay. |
| Details |
Background information
Clone FGK45.5 recognizes the mouse CD40 antigen, a 40–50 kDa glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed on B lymphocytes, macrophages, and dendritic cells and is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other antigen-presenting cells (APCs). The interaction of CD40 on B cells with its ligand CD154 is involved in B cell activation and differentiation; engagement of CD40 on dendritic cells leads to maturation. Clone FGK45 can be used for blocking of CD40/CD154 interaction and for in vitro and in vivo activation of CD40-expressing APCs. |
| Clone | Isotype |
| FGK45.5 | Rat IgG2a |
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