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| Anti-GITR – functional grade |
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| Overview |
Anti-GITR – functional grade is suitable for use in in vitro and in vivo functional assays. The antibody is free of azide and preservatives. Endotoxin level is <0.01 ng/µg protein as tested by LAL assay.
Reported applications of clone DTA-1 include
- in vitro costimulation of T cells,
- in vivo GITR stimulation,
- abrogation of regulatory T cell function.
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| Details |
Background information
Clone DTA-1 specifically recognizes mouse GITR (Glucocorticoid-induced TNF-receptor), a member of the TNF receptor superfamily1 also known as TNFRSF182. It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ regulatory T cells (Tregs). Activation of T cells upregulates GITR expression. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. GITR plays an important role in the function of CD4+CD25+ Tregs.3 |
| Clone | Isotype |
| DTA-1 | Rat IgG2b |
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| Details |
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| References |
| 1. Nocentini et al. (1997) Proc. Natl. Acad. Sci. USA 94: 6216–6221. |
| 2. Gurney et al. (1999) Curr. Biol. 9: 215–218. |
| 3. Nocentini et al. (2007) Eur. J. Immunol. 37: 1165–1169. |
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