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| CD279 (PD-1) – functional grade |
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| Overview |
| Clone HA2-7B1.3 can be used for blocking of binding of CD279 (PD-1) to its ligands B7-H1 and PD-L2. The antibody is free of azide and preservatives. Endotoxin level is below 0.01 ng/µg protein as tested by LAL assay. |
| Details |
Background information
CD279, also known as PD-1 (programmed death-1), is a 55 kDa member of the Ig superfamily expressed mainly on activated T and B lymphocytes. Expression is induced on activated myeloid cells as well. CD279 (PD-1) is thought to be involved in lymphocyte clonal selection and plays a key role in peripheral tolerance and autoimmune disease in mice. The ligands of CD279 (PD-1), PD-L1 (B7-H1) and PD-L2 (B7-DC), belong to the B7 immunoglobulin superfamily. Clone HA2-7B1 has been used to block the binding of PD-1 to its ligands.1-4 . |
| Clone | Isotype |
| HA2-7B1 | rat IgG2b |
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| Favorites / Prices |
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| Details |
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| Products |
| CD279 (PD-1) pure – functional grade, mouse |
- 500 µg in 1 mL
Download datasheet
130-094-944
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| References |
| 1. Hirano, F. et al. (2005) Cancer Res. 65: 1089–1096. |
| 2. Iwai, Y. et al. (2002) PNAS 99: 12293–12297. |
| 3. Salama, A. D. et al. (2003) J. Exp. Med. 198: 71–78. |
| 4. Tsushima, F. et al. (2007) Blood 110: 180–185. |
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