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| Overview |
| The antibody clone A7R34 reacts with CD127, also known as IL-7 receptor α chain (IL-7Rα), The pure – functional grade antibody is suited for functional assays, for example, in vitro and in vivo blocking of IL-7 binding to its receptor. |
| Details |
Background information
Mouse CD127 is a 60–90 kDa type-I transmembrane glycoprotein. It is a component of the high affinity IL-7 receptor (IL-7R) and the receptor for thymic stromal lymphopoietin (TSLP) 1. CD127 is expressed on immature B cells; CD4-CD8-, CD4+, and CD8+ thymocytes; naive and memory T cells; thymic NK cells; and bone marrow stromal cells 2,3. Upon activation of naive T cells, CD127 expression is downregulated. Re-expression of CD127 identifies the effector cells that will differentiate into memory T cells 4. |
| Clone | Isotype |
| A7R34 | Rat IgG2a |
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| Favorites / Prices |
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| Details |
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| Products |
| CD127 pure – functional grade, mouse |
- 1 mg in 0,5 mL
Download datasheet
130-094-828
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| References |
| 1. Goodwin, R. G. et al. (1990) Cell 60: 941–951. |
| 2. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. USA 90: 9125–9129. |
| 3. Vosshenrich, C. A. et al. (2006) Nat Immunol. 7: 1217–1224. |
| 4. Kaech, S. M. et al. (2003) Nat. Immunol. 4: 1191–1198. |
| 5. Colpitts, S. L. et al. (2009) J. Immunol. 182: 5702–5711. |
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