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| Anti-GITR – functional grade |
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| Overview |
| The functional grade antibody is suitable for in vitro functional assays and is free of azide and preservatives. Endotoxin level is <0.01 ng/µg protein as tested by LAL assay. |
| Details |
Background information
Clone DT5D3 recognizes human GITR (glucocorticoid-induced TNF receptor family-regulated gene), a type I transmembrane protein also known as AITR or TNFRSF18. GITR is expressed at low levels on resting T lymphocytes, expression is upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, and cytokine production. GITR signaling has been shown to regulate TCR-mediated apoptosis. GITR plays an important role in the function of CD4+CD25+ Tregs. |
| Clone | Isotype |
| DT5D3 | Mouse IgG1 |
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| Favorites / Prices |
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| Details |
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| Products |
| Anti-GITR pure – functional grade, human |
- 0.5 mg in 0.5 mL
Download datasheet
130-093-052
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