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| Overview |
| The antibody is suitable for functional assays, e.g., for stimulation of human or non-human primate cells in suspension. It is free of azide and preservatives. Endotoxin level is <0.01 ng/µg of protein as tested by LAL assay. |
| Details |
Background information
The HB 14 monoclonal antibody reacts with human CD40, a 45–50 kDa type I transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed primarily on B cells, macrophages, follicular dendritic cells, endothelial cells, and fibroblasts and at lower levels on plasma cells and a subset of peripheral T cells. CD40 is involved in B cell differentiation and proliferation, isotype class-switching, and protection of B cells from apoptosis. Interaction of CD40 with its ligand CD154 is important in T cell–B cell interaction and plays a role in costimulation and immune regulation.
Clone HB14 blocks the binding of CD40 to CD154. This prevents down-regulation of CD154 expression induced by interaction with CD40 expressed on antigen-presenting cells. |
| Cross-reactivity |
This antibody is tested to cross-react with - Rhesus monkey (Macaca mulatta)
- Cynomolgus monkey (Macaca fascicularis)
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| Clone | Isotype |
| HB14 | Mouse IgG1 |
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| Favorites / Prices |
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| Details |
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| Products |
| CD40 pure – functional grade, human |
- 100 μg in 1 mL
Download datasheet
130-094-133
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