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| Overview |
| IL-4 stands for interleukin 4. Mouse IL-4 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
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Background information
IL-4 is produced mainly by activated Th2 cells and, to a lesser extent, by Th1 cells. It binds to the IL-4 receptor α (CD124), followed by the dimerization with other receptor chains to generate type 1 and type 2 receptors. IL-4 promotes the proliferation and differentiation of activated B cells and the expression of MHC class II antigens. Mice over expressing IL-4 have elevated levels of IgE and IgG1 and show a deficiency in T cell maturation. CD4+ T cells from knockout mice lacking IL-4 are not able to produce Th2 cytokines after in vitro stimulation. The biological activity of IL-4 is species-specific, i.e. murine IL-4 is inactive on human cells and vice versa.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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