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| Overview |
| IL-1α stands for interleukin 1α. Mouse IL-1α is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information
IL-1α is a monomeric protein belonging to the IL-1 family which also comprises IL-1β (IL-1β). Both IL-1α and IL-1β bind to the same receptor and therefore also show similar if not identical biological activities. A key function of IL-1α and IL-1β is the stimulation of T helper cells by inducing IL-2 release. Furthermore, IL-1 is involved in B cell maturation and proliferation and has fibroblast growth factor activity. IL-1, in combination with other cytokines, plays a significant role in the the development of inflammatory responses. IL-1α is the predominant IL-1 form in mouse. In mice, a transition from IL-1β to IL-1α production during maturation of monocytes into inflammatory macrophages can be observed. Murine TH17 cells develop in response to IL-1 and other cytokines.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
| Alternative names |
| BAF, BCAF, LAF, LEM,.. |
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