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| Overview |
| IFN-γ stands for interferon gamma. Mouse IFN-γ is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
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Background information
IFN-γ is a homodimer produced by a variety of immune cells, mainly activated T cells and NK cells. In addition to its antiviral activity, IFN-γ is a potent activator of macrophages, has antiproliferative effects on transformed cells and can potentiate the antiviral and antitumor effects of type I interferons. Transgenic mice expressing IFN-γ in the pancreas have been shown to develop autoimmune diabetes, caused by infiltration of lymphocytes. IFN-γ knockout mice develop normally, but are highly susceptible to infection with low numbers of certain intracellular bacterial pathogens and fungi. Mouse IFN-γ shows approximately 40% amino acid sequence homologous with human IFN-γ. It is highly specific without showing cross reactivity between species.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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