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| Mouse RANK-Ligand – soluble |
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| Overview |
| RANK-Ligand stands for receptor activator of NF-κB ligand, also termed TNSFSF11 or TRANCE. Mouse RANK-Ligand is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information
RANK-Ligand is a member of the tumor necrosis factor family. It is a homotrimeric factor and interacts with two receptors - one functional, RANK (TNFRSF11A), and one decoy receptor, OPG (TNFRSF11B). RANK-Ligand exists as a soluble and a transmembrane form (also known as CD254). The membrane-bound form is extensively expressed on osteoblasts and bone marrow stromal cells, whereas soluble RANK-Ligand is predominantly secreted by activated T cells. RANK-Ligand acts as osteoclast differentiation and activation factor and is a key regulator of bone remodeling and mammary gland development. Intriguingly, RANK-Ligand/RANK interactions also regulate communications between T cells and dendritic cells, dendritic cell survival, and lymph node formation. Mice lacking RANK suffer from osteopetrosis, are deficient in osteoclasts, and have a profound defect in bone resorption and remodeling.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
| Alternative names |
| TNSFSF11, TRANCE, OPGL |
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