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| Overview |
| IL-15 stands for interleukin 15. Mouse IL-15 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information IL-15 is a member of the four α-helix bundle cytokine family. It is produced by different cell types, including epithelial cells, monocytes, muscle, and placenta cells. IL-15 is a potent lymphoid cell growth factor and shares many biological properties with IL-2. Like IL-2, IL-15 stimulates the proliferation of activated T cells and promotes the generation of cytotoxic T lymphocytes (CTLs). IL-2 and IL-15 also induce the generation, proliferation, and activation of NK cells as well as B cell growth and immunoglobulin production. In addition, IL-15 is important for the maintenance of CD8+ memory T cells. For binding and signaling IL-15 uses the unique IL-15 receptor α-chain, but shares the β- and γ-chain of the IL-2 receptor. Quality description Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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