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| Overview |
M-CSF stands for macrophage-colony stimulating factor. Mouse M-CSF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Mouse M-CSF can be used for a variety of applications, including:
- Generation of bone marrow-derived macrophages1.
- In vivo induction of DC generation.
- Differentiation of osteoclasts.
- Proliferation and apoptosis assays.
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| Details |
Background information
M-CSF, a four α-helical bundle cytokine, is a potent hematopoietic regulator. It is primarily produced by monocytes, granulocytes, endothelial cells, and fibroblasts. The main function of M-CSF is the regulation of proliferation, differentiation, and survival of monocytes, macrophages and their hematopoietic progenitors. Furthermore, M-CSF has been shown to play an important role in immunological defense, bone metabolism, fertility, and pregnancy.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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| Details |
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| References |
| 1. Tanne et al. (2009) J. Exp. Med. 206:2205-2220 |
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