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| Overview |
| SCF stands for stem cell factor, also termed c-Kit ligand. Mouse SCF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information
SCF is a non-covalently linked homodimer that plays an important role in hematopoiesis. SCF exists as a soluble and a transmembrane form and signals through the tyrosine kinase receptor c-kit (CD117). SCF stimulates the proliferation and differentiation of various cell types, including hematopoietic stem cells, mast cells, melanocytes, and germ cells. In vitro, SCF is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors and synergizes with other growth factors, including G-CSF, GM-CSF, IL-3, and IL-6 to stimulate the proliferation and differentiation of cells of the lymphoid, myeloid, erythroid, and megakaryocytic lineages. The mouse protein displays 82% sequence identity with the human factor. Mouse SCF is active on human cells, while human SCF is much less active on mouse cells.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
| Alternative names |
| c-kit ligand, steel factor, MGF |
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