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| Overview |
TPO stands for thrombopoietin, also termed thrombopoiesis stimulating factor (TSF). Human TPO is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Human TPO can be used for a variety of applications, including:
- Megakaryocyte proliferation and differentiation in vitro.
- In vitro expansion of CD34+ hematopoietic progenitor cells.
- Differentiation of ES-derived cells towards the hematopoietic lineage.
- In vitro platelet activation.
- Apoptosis assays.
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| Details |
Background information
TPO is a glycoprotein hormone and the major stimulator of megakaryopoiesis and platelet production. TPO is expressed in liver, kidney, spleen, lung, bone marrow, and brain. The TPO receptor is a product of the proto-oncogene c-mpl and displays homology with type I cytokine receptor superfamily members. The receptor is present mainly on hematopoietic stem cells, megakaryocytic progenitors, megakaryocytes, and platelets. TPO is the primary regulator of platelet production by megakaryocytes. It stimulates the proliferation of hematopoietic stem cells, primitive progenitors, megakaryocytes, and platelets. Analogous to the effect of erythropoietin (EPO), the primary mode of action of TPO is inhibition of apoptosis of its target cells. By contrast, TPO is strongly proapoptotic in the brain and acts as a counterpart of EPO which has neuroprotective properties.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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