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| Overview |
| MCP-1 stands for monocyte chemotactic protein 1, also termed monocyte chemotactic and activating factor (MCAF) or CCL2. Human MCP-1 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. |
| Details |
Background information
MCP-1 belongs to the CC chemokine subfamily and signals predominantly through CCR2. MCP-1 is expressed by various cell types and besides monocyte and tissue macrophages also attracts T cells and NK cells to sites of inflammation. In addition to chemotaxis further pro-inflammatory activities, such as all activation, angiogenesis, and fibrosis are attributed to MCP-1.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
| Alternative names |
| CCL2, MCAF |
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