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| Overview |
IL-22 stands for interleukin 22, also termed IL-10-related T cell-derived inducible factor (IL-TIF). Human IL-22 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Human IL-22 can be used for a variety of applications, including:
- In vitro stimulation of keratinocytes, hepatocytes, and mecrophages.
- Migration and proliferation assays, e.g. in the context of wound healing and tissue regeneration.
- Investigation of IL-22 mediated signaling pathways.
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| Details |
Background information
IL-22 is a member of the IL-10 family which consists of potent mediators of cellular inflammatory response. IL-22 is expressed by innate and adaptive immune cells, including NK cells, lymphoid tissue inducer-like cells, TH17 cells, and TH22 cells. IL-22 acts directly on nonhematopoietic cells. It induces its signals through a two-component receptor comprised of IL-22R1 and IL10Rβ, belonging to the class II cytokine receptor family. The receptor is expressed only on the surface of epithelial cells and some fibroblasts in organs like gut, lung, skin, and liver. IL-22 has been shown to act cooperatively with IL-17A and IL-17F to enhance expression of acute-phase proteins. Members of the IL-10 family show partial homology in their amino acid sequences, but show distinct biological functions. Human and mouse IL-22 proteins share 81% amino acid identity.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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