|
|
 |
|
| Overview |
TSLP stands for thymic stromal lymphopoietin. Human TSLP is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Human TSLP can be used for a variety of applications, including:
- Activation of immature DCs.
- Expansion, differentiation, and activation of B cells.
- Support in T cell growth and survival.
- Studies on initiation of allergic diseases.
|
| Details |
Background information
TSLP is a hematopoietic cytokine that plays a critical role as regulator of T helper (TH)2 driven inflammation. It is highly expressed in skin keratinocytes and airway epithelial cells as well as in gut and thymus. TSLP is an interleukin 7 (IL-7)-like cytokine that binds to a heterodimeric receptor complex consisting of the alpha chain of the IL-7 receptor (IL-7Rα) and the TSLP receptor chain (TSLPR). It is able to promote the activation of B cells and dendritic cells (DCs). TSLP activated DCs polarize naive CD4+ T cells to differentiate into inflammatory TH2 cells that produce the pro-allergic cytokines IL-4, IL-5, IL-13, and TNF-α. Furthermore TSLP supports B cell expansion and differentiation. It induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c+ DCs. Like IL-7, TSLP has been shown to activate and phosphorylate the transcription factors STAT3 and STAT5.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
| | |
|
|
| Favorites / Prices |
Request prices or add products to your favorite list.
|
| Details |
|
|
|
© 1999 - 2012 Miltenyi Biotec ¦ Terms & conditions ¦ Legal notes
|
