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| Overview |
ANGPTL5 stands for angiopoietin-like 5, also termed angiopoietin-like protein 5 or angiopoietin-related protein 5. Human ANGPTL5 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Human ANGPTL5 can be used for a variety of applications, including:
- Ex vivo expansion of human hematopoietic stem cells.
- Studies of lipoprotein metabolism or angiogenesis.
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Background information
ANGPTL5 is a secreted factor with high homology to angiopoietins which are important regulators of angiogenesis. Angiopoietins bind to the angiopoietin-specific receptor TIE-2, whereas angiopoietin-like proteins do not bind to this receptor. The receptor for ANGPTL5 is not yet known. Due to a coiled-coil domain, which can interact with the extracellular matrix, they exist primarily as homooligomers. Angiopoietin-like proteins are potent regulators of angiogenesis either proangiogenic or antiangiogenic factors, suggesting that their receptors may be expressed on endothelial cells. They also show pleiotropic effects on cells of other lineages, such as skin cells and chondrocytes. Angiopoietin-like proteins play a role in lipid and triglyceride metabolism and vertebrate development. It has been shown that ANGPTL5 stimulates the ex vivo expansion of human cord blood hematopoietic stem cells.
Quality description
Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/µg (<1 EU/µg), and purities are >95%. The biological activity is tested in appropriate bioassays. |
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