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| Description |
PepTivator® Tyrosinase is a peptide pool that consists mainly of 15-mer peptides with 11–amino acid (aa) overlap.
PepTivator peptide pools have been developed for the efficient in vitro stimulation of antigen–specific CD4+ and CD8+ T cells as peptides of 15-aa length with 11-aa overlap represent an optimized solution for stimulating both CD4+ and CD8+ T cells in various applications.1
Quantitative, phenotypical, or functional analysis of tyrosinase-specific T cell immunity can provide important information on the natural course of immune responses. |
| Details |
Background information
Besides gp100/Pmel17 and Melan-A/MART-1, tyrosinase belongs to the melanoma-associated antigens of the group of differentiation antigens. It is expressed on normal melanocytes, but is also present in melanoma. Accordingly, CD4+ and CD8+ T lymphocytes recognizing tyrosinase have been identified in melanoma patients. Therefore, tyrosinase represents a potential target for immunotherapy of melanoma2.
Downstream applications
The in vitro stimulation of tyrosinase-specific CD4+ and CD8+ T cells with PepTivator Tyrosinase causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of tyrosinase–specific T cells.
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| Details |
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| Products |
| PepTivator Tyrosinase, human |
- 6 nmol/peptide for stimulation of 108 cells
Download datasheet
130-094-445
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- 60 nmol/peptide for stimulation of 109 cells
Download datasheet
130-094-446
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| References |
| 1. Kieker et al. (2004) Hum. Immunol. 65: 523–536. |
| 2. Boon, T. et al. (2006) Annu. Rev. Immunol. 24: 175–208. |
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