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| CD271 (LNGFR) MicroBead Kit |
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| Description |
The CD271 (LNGFR) MicroBead Kit is an indirect labeling system for the immunomagnetic isolation of CD271 (LNGFR)+ cells. The kit includes all necessary reagents for fluorescent labeling (CD271 (LNGFR)-PE or -APC) and indirect magnetic labeling (Anti-PE or -APC MicroBeads) of CD271 (LNGFR)+ cells, as well as FcR Blocking Reagent for the prevention of unspecific labeling via Fc receptors.
CD271, also known as LNGFR (low-affinity nerve growth factor
receptor), NGFR (nerve growth factor receptor), or p75NTR
(neurotrophin receptor), belongs to the tumor necrosis factor
receptor superfamily. CD271 (LNGFR) was initially described to be
expressed on cells of the nervous system and was suggested to be
involved in the development, survival and differentiation of neural
cells.Ā¹ CD271 (LNGFR) can be found in the central and peripheral
nervous system on autonomic and sensory neuronsĀ² as well as
on glial cells, including oligodendrocytesĀ³, astrocytesā“, Schwann
cells5,6, and neural crest precursors7. |
| Applications |
Positive selection or depletion of cells expressing human CD271 (LNGFR).
Positive selection of neural cells, including neural crest cells, motor neurons, and Schwann cells. |
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| MACS References |
| 1. Thomson, T. M. et al. (1988) Exp. Cell Res. 174 (2): 533ā539. |
2. Kashiba, H. et al. (1995) Brain Res. Mol. Brain
Res. 30 (1): 158ā164. |
3. Casaccia-Bonnefil, P. et al. (1996) Nature 383 (6602): 716ā
719. |
| 4. Rudge, J. S. et al. (1994) Eur J. Neurosci. 6 (5): 693ā705. |
| 5. DiStefano, P. S. and Johnson, E. M. Jr. (1988) Proc. Natl. Acad. Sci. USA 85 (1): 270ā274. |
| 6. Vroemen, M. and Weidner, N. (2003) J. Neuroscience Methods 124 (2): 135ā143. |
| 7. Chalazonitis, A. et al. (1998) Dev Biol. 204 (2): 385ā406. |
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