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| Description |
| CD133 is regarded as an important marker for the identification and isolation of primitive stem and progenitor cells from both hematopoietic and nonhematopoietic tissues. CD133+ cells have shown a capacity for pluripotent tissue differentiation, including to neural lineages1. CD133+ isolated from fetal liver2, umbilical cord blood3, bone marrow4, mobilized blood5, and skin6are capable of in vitro differentiation to neuronal cells as well as to astrocytes2,3, 5, oligodendrocytes3,5, and glial cells3. CD133+ cells are also found in the human fetal brain and are therefore regarded as neural stem and progenitor cells. CD133+ cells isolated from human fetal brain7-11 were able to form self-renewing neurospheres in vitro, and to differentiate into neurones7,11 and glia7, 11. Moreover, when injected into mice, human CD133+ cells differentiated into fully integrated neurones and glial cells8,10 as well as astrocytes and endothelial cells6. |
| Applications |
| CD133+ cells have the capacity to differentiate into neural lineages, and are therefore regarded as neural stem and progenitor cells. CD133+ cells are used in basic neural stem cell research, evaluation, and expansion. |
| Clone | Isotype |
| AC133 | Mouse IgG1 |
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| Figure 1 |
| Oligodendrocyte-like cells derived from the in vitro differentiation of magnetically selected CD133+ cells. Courtesy of Selim Kuçi, Tübingen, Germany. |
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| Details |
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| References |
| 1. Kuci et al. (2004) Abstract 2nd International Meeting, Stem Cell Network, North-Rhine Westphalia. |
| 2. Hao et al. (2003) J. Hematother. Stem Cell Res. 12: 23–32. |
| 3. Jang et al. (2004) J. Neurosci. Res. 75: 573–584. |
| 4. Padovan et al. (2003) Cell Transp. 12: 839–848. |
| 5. Piechaczek et al. (2002) Stem Cell Research Customer Report 2–3. |
| 6. Belicchi et al. (2004) J. Neurosci. Res. 77: 475–486. |
| 7. Uchida et al. (2000) Proc. Natl. Acad. Sci. USA 97: 14720–14725. |
| 8. Tamaki et al. (2002) J. Neuro. Res. 69: 976–986. |
| 9. Kelly et al. (2004) Proc. Natl. Acad. Sci. USA 101: 11839–11844. |
| 10. Cummings et al. (2005) Proc. Natl. Acad. Sci. USA 102: 14069–14074. |
| 11. Yu et al. (2004) Biotech. Let. 26: 1131–1136. |
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