| Description |
| CD19 MicroBeads were developed for direct magnetic isolation of CD19+ B cells. As a B cell lineage marker, the CD19 antigen is expressed from the early pro-B cell stage to the B cell lymphoblast stage, but the expression is down-regulated upon B cell maturation to plasma cells. The CD19 antigen is further expressed on most malignant B cells and on a subset of follicular dendritic cells. |
| Applications |
CD19 MicroBeads can be used for purification or depletion of lineage B cells from many different cell sources, e.g., human PBMCs, bone marrow, lymphoid tissues, or cell cultures. Isolated CD19+ B cells were used for studies on immunoglobulin production, such as IgE synthesis1, 2 and secretion3, chemotaxis assays4, or mixed lymphocyte reactions. Positively selected CD19+ B cells were also used for molecular studies such as gene expression profiling.5 For the analysis of minimal residual diseases in B cell malignancies, enrichment of B cells increases the sensitivity of detection.6
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